Endocrine Abstracts

The N-terminal fragment of human POMC consists of a 76 residue peptide (also known as pro-gamma-MSH) that contains the sequence of gamma-MSH in its C-terminus. Previous studies have demonstrated that the N-terminal portion not containing the gamma-MSH sequence is a potent adrenal mitogen while gamma-MSH itself can act synergistically with ACTH to increase steroid output.Since previous studies [1] have suggested that N-POMC 1-28 can stimulate the ERK path...